Part I
Biological Occurence and Biosynthesis
Naturally Occurring Anthracyclines
H. Laatsch, S. Fotso ............................................ 3
Biosynthetic Anthracycline Variants
J. Niemi, M. Metsä-Ketelä, G. Schneider, P. Mäntsälä ........... 75
Anthracycline Biosynthesis: Genes, Enzymes and Mechanisms
M. Metsä-Ketelä, J. Niemi, P. Mäntsälä, G. Schneider .......... 101
Part II
Synthesis and Chemistry
Synthesis of Enantiomerically Pure Anthracyclinones
O. Achmatowicz, B. Szechner ................................... 143
Combinatorial Synthesis of Linearly Condensed Polycyclic
Compounds, Including Anthracyclinones, Through Tandem
Diels-Alder Additions
P. Vogel ...................................................... 187
Fluorinated Anthracyclines
G. Giannini, D. Alloatti ...................................... 215
Synthesis of the Sugar Moieties
G. Grynkiewicz, W. Szeja ...................................... 249
Nonnatural Glycosyl Anthraquinones as DNA Binding and
Photocleaving Agents
K. Toshima .................................................... 285
Syntheses of Anthracyclines and Fredericamycin A via Strong
Base-Induced Cycloaddition Reaction of Homophthalic
Anhydrides
Y. Kita, H. Fujioka ........................................... 299
Subject Index ................................................. 321
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