Preface ....................................................... vii
Chapter I. Clinical Application of RNAi: Novel Strategies
for Cancer Therapy ................................. 1
Kinya Okamoto and Matthias Ocker
Chapter II. Natural Grp78 Antisense RNA Induces Apoptosis by
Creating a Chimeric mRNA with Msh4 pre-mRNA ....... 27
Masanori Hirano
Chapter III. Selection of Target Sites in RNA for
Antisense Agents .................................. 71
Jian-Ying Wang and Karl Drlica
Chapter IV. Silencing the Brain by RNA Interference:
A Promising Approach for Therapeutic Use .......... 91
Yukio Akaneya
Chapter V. Natural Antisense RNA in Mammals: New
Characteristics Revealed by Recent Genome-Wide
Expression Analysis .............................. 109
Yuki Hasegawa and Hidenori Kiyosawa
Chapter VI. Sequence Requirements for Effective Mammalian
RNAi Induced by Short Double-Stranded RNAs
Equal to or More than 22bp in Length ............. 141
Kumiko Ui-Tei, Shuhei Zenno and Kaoru Saigo
Chapter VII. Effects of Anti-K-Ras and Anti-Telomerase
Phosphorothioate Antisense Oligodeoxy-
nucleotides on Colorectal Cancer Growth .......... 161
R. Alfonso, M.J. Herrero, F. Dasi, S.F.
Aliño and S. Lledo
Chapter VIII.Antisense Strategy, Targeting for Microtubule-
Associated Protein and other Proteins in
Glioma Cells ..................................... 179
Akira Matsuno
Chapter IX. Oligodeoxynucleotide Expression Library for
Discovery of Novel Antibiotics ................... 199
Xin-Xing Tan and Yin Chen
Index ......................................................... 213
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