Tubulin-binding agents: synthetic, structural and mechanistic insights / ed. by Carlomagno T.; with contributions by Altmann K.-H. et al. - Berlin; Hedelberg: Springer, 2009. - xi, 331 p.: ill. - (Topics in current chemistry; 286). - Ind.: p.329-331. - ISBN 978-3-540-69036-8; ISSN 1436-5049  Место хранения:   01 | ГПНТБ СО РАН | Новосибирск

Contents

Macrolide-Based Microtubule-Stabilizing Agents - Chemistry and Structure-Activity Relationships .................. 1 B. Pfeiffer, C.N. Kuzniewski, С Wullschleger, and K.-H. Altmann The Chemical Synthesis of Discodermolide ....................... 73 I. Paterson and G.J. Florence The Interaction of Microtubules with Stabilizers Characterized at Biochemical and Structural Levels ............ 121 J.F. Diaz, J.M. Andreu, and J. Jimenez-Barbero The Tubulin Binding Mode of MT Stabilizing and Destabilizing Agents Studied by NMR ........................... 151 Victor M. Sanchez-Pedregal and Christian Griesinger The Tubulin Binding Mode of Microtubule Stabilizing Agents Studied by Electron Crystallography .................... 209 James H. Nettles and Kenneth H. Downing Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin .................................. 259 B. Gigant, A. Cormier, A. Dorleans, R.B.G. Ravelli, and M. Knossow Molecular Modeling Approaches to Study the Binding Mode on Tubulin of Microtubule Destabilizing and Stabilizing Agents ........................................................ 279 Maurizio Botta, Stefano Forli, Matteo Magnani, and Fabrizio Manetti Index ......................................................... 329