Preface ......................................................... v
Contributors ................................................... ix
1. Drug Delivery Systems - An Overview .......................... 1
Kewal K. Jain
2. The Role of the Adeno-Associated Virus Capsid in Gene
Transfer .................................................... 51
Kim M. Van Vliet, Veronique Blouin, Nicole Brument,
Mavis Agbandje-McKenna, and Richard O. Snyder
3. Delivering Small Interfering RNA for Novel Therapeutics ..... 93
Patrick Y. Lu and Martin C. Woodle
4. Catheters for Chronic Administration of Drugs
into Brain Tissue .......................................... 109
Michael Guarnieri, Benjamin S. Carson, Sr., and
George I. Jallo
5. Transdermal Drug Delivery Systems: Skin Perturbation
Devices .................................................... 119
Marc B. Brown, Matthew J. Traynor, Gary P. Martin,
and Franklin K. Akomeah
6. Controlling the Release of Proteins/Peptides via the
Pulmonary Route ............................................ 141
Sunday A. Shoyele
7. Engineering Protein Particles for Pulmonary Drug
Delivery ................................................... 149
Sunday A. Shoyele
8. 2B-TransTM Technology: Targeted Drug Delivery Across the
Blood-Brain Barrier ........................................ 161
Pieter J. Gaillard and Albertus G. de Boer
9. Drug Delivery in Cancer Using Liposomes .................... 177
Crispin R. Dass
10.pH-Responsive Nanoparticles for Cancer Drug Delivery ....... 183
Youqing Shen, Huadong Tang, Maciej Radosz, Edward
Van Kirk, and William J. Murdoch
11.Extended-Release Oral Drug Delivery Technologies:
Monolithic Matrix Systems .................................. 217
Sandip B. Tiwari and Ali R. Rajabi-Siahboomi
Index ......................................................... 245
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