Preface ....................................................... xii
1. Structure and Membrane Interactions of Antimicrobial
Peptides Viewed by Solid-State NMR Spectroscopy .............. 1
Marise Ouellet and Michele Auger
1. Introduction .............................................. 2
2. Study of Antimicrobial Peptides in Membranes ............. 3
3. Effects of Antimicrobial Peptides on Model Lipid
Membranes ................................................ 15
4. Conclusions .............................................. 19
References .................................................. 19
2.Chemical Exchange ............................................ 23
Alex D.Bain
1. Introduction ............................................. 23
2. Overview, Trends and Opinions ............................ 25
3. Theory ................................................... 27
4. Methodology .............................................. 32
5. Applications ............................................. 35
6. Conclusions and Acknowledgments References ............... 43
3. Rhodium-103 NMR ............................................. 49
Laurence Carlton
1. Introduction ............................................. 50
2. Acquisition of Data ...................................... 51
3. Calibration of Spectra ................................... 52
4. Factors Underlying the Chemical Shift .................... 54
5. Influence of Temperature on the Chemical Shift ........... 57
6. Influence of Solvent on the Chemical Shift ............... 58
7. Other Influences on the Chemical Shift ................... 61
8. Correlation of δ(103Rh) with Chemical and
Structural Parameters .................................... 65
9. Parahydrogen-lnduced Polarisation (PHIP) ................. 76
10.High-Pressure Studies .................................... 78
11.Solid-State Studies ...................................... 78
12.Clusters ................................................. 80
13.Calculated Chemical Shifts ............................... 82
14.Spin Coupling Constants .................................. 84
15.Relaxation Times ......................................... 87
16.Conclusion ............................................... 88
Abbreviations ............................................ 88
Acknowledgements ......................................... 90
Appendix: Layout of Tables ............................... 90
References .............................................. 167
4. The Indirect Detection of Metal Nuclei by Correlation
Spectroscopy (HSQC and HMQC) ............................... 179
Jonathan A.Iggo, Jianke Liu and Gillian Overend
1. Introduction ............................................ 180
2. 2D NMR Spectroscopy ..................................... 186
3. Spin Systems ............................................ 200
4. Review of Recent Reports of the Indirect Detection
of Metal Nuclei ......................................... 211
5. Conclusions ............................................. 255
Abbreviations ................................................. 255
Acknowledgements .............................................. 257
References .................................................... 257
Subject Index ................................................. 263
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