Contributors .................................................. vii
Preface ........................................................ ix
1 Chemical Biology Based on Small Molecule—Protein
Interaction .................................................. 1
Hiroyuki Osada
2 Target Profiling of Small Molecules ......................... 11
Leonid L. Chepelev and Michel Dumontier
3 Novel Applications of Affinity Beads ........................ 39
Yasuaki Kabe, Mamoru Hatakeyama, Satoshi Sakamoto, Kosuke
Nishio, and Hiroshi Handa
4 Recent Developments and Advances in Chemical Arrays ......... 57
Naoki Kanoh and Hiroyuki Osada
5 Use of the Phage Display Technique to Identify the Target
Protein ..................................................... 81
Yoon Sun Cho and Ho Jeong Kwon
6 Development of Fluorescent Probes for Small Molecules ....... 91
Adrian P. Neal and Carsten Schultz
7 Development of Small-Molecule Ligands and Inhibitors ....... 115
Leonid L. Chepelev, Nikolai L. Chepelev, Hooman Shadnia,
William G. Willmore, James S. Wright, and Michel
Dumontier
8 Interaction of a Biological Response Modifier with
Proteins ................................................... 149
Yuichi Hashimoto
9 Chemical Biology of Cell Motility Inhibitors ............... 169
Tatsuro Kawamura, Mitsuhiro Kitagawa, and Masaya Imoto
10 Chemical Biology of Cell Surface Oligosaccharides .......... 189
Prabhani U. Atukorale, Sean S. Choi, Udayanath Aich,
Christopher T. Campbell, M. Adam Meledeo, and Kevin
J. Yarema
11 Chemical Genomics Based on Yeast Genetics .................. 223
Shinichi Nishimura, Yoko Yashiroda, and Minoru Yoshida
12 Data on Small Molecules and Their Target Proteins .......... 239
Takeo Usui, Akiko Saito, and Hiroyuki Osada
Index ......................................................... 277
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