Enzyme technologies: metagenomics, evolution, biocatalysis, and biosynthesis / ed. by Wu-Kuang Yeh, Hsiu-Chiung Yang, J.R.McCarthy. - Hoboken: Wiley, 2010. - xi, 368 p., [8] p. - (Chemical biology of enzymes for biotechnology and pharmaceutical applications; vol.1). - Ind.: p.363-368. - ISBN 978-0-470-28624-1  Место хранения:   021 | Институт цитологии и генетики CO РАН | Новосибирск | Библиотека

Оглавление / Contents

Contributors .................................................. vii Preface ........................................................ ix PART A NEW APPROACHES TO FINDING AND MODIFYING ENZYMES ......... 1 1 Functional Metagenomics as a Technique for the Discovery of Novel Enzymes and Natural Products ........................... 3 Luke А. Мое, Matthew D. McMahon, and Michael G. Thomas 2 Directed Enzyme and Pathway Evolution ....................... 41 Jacob Vick and Claudia Schmidt-Dannert 3 Combining Natural Biodiversity and Molecular-Directed Evolution to Develop New Industrial Biocatalysts and Drugs ....................................................... 77 Laurent Fourage, Céline Ayrinhac, Johann Brot, Christophe Ullmann, Denis Wahler, and Jean-Marie Sonet 4 Principles of Enzyme Optimization for the Rapid Creation of Industrial Biocatalysts .................................. 99 Richard J. Fox and Lori Giver PART В BIOCATALYTIC APPLICATIONS ............................. 125 5 Enzyme Catalysis in the Synthesis of Active Pharmaceutical Ingredients ................................. 127 Animesh Goswami 6 Enzymatic Processes for the Production of Pharmaceutical Intermediates .............................................. 185 David Rozzell and Jim Lalonde 7 Novel Developments Employing Redox Enzymes: Old Enzymes in New Clothes ............................................. 199 Kurt Faber, Silvia M. Glueck, Birgit Seisser, and Wolfgang Kroutil PART С BIOSYNTHETIC APPLICATIONS ............................. 251 8 Drug Discovery and Development by Combinatorial Biosynthesis ............................................... 253 Matthew A. DeSieno, Carl A. Denard, and Huimin Zhao 9 Reprogramming Daptomycin and A54145 Biosynthesis to Produce Novel Lipopeptide Antibiotics ...................... 285 Richard H. Baltz, Kien Т. Nguyen, and Dylan C. Alexander 10 Pathway and Enzyme Engineering and Applications for Glycodiversification ....................................... 309 Lishan Zhao and Hung-wen Liu Index ......................................................... 363