Foreword ...................................................... vii
Preface ........................................................ ix
List of Contributors ........................................... xi
1 Chemical Synthesis of Modified RNA ........................... 1
Claudia Hobartner and Falk Wachowius
2 Expansion of the Genetic Alphabet in Nucleic Acids by
Creating New Base Pairs ..................................... 39
Ichiro Hirao and Michiko Kimoto
3 Chemical Biology of DNA Replication: Probing DNA
Polymerase Selectivity Mechanisms with Modified
Nucleotides ................................................. 63
Andreas Marx
4 Nucleic Acid-templated Chemistry ............................ 73
Michael Oberhuber
5 Chemical Biology of Peptide Nucleic Acids (PNAs) ........... 103
Peter E. Nielsen
6 The Interactions of Small Molecules with DNA and RNA ....... 115
Yun Xie, Victor K. Tarn and Yitzhak Tor
7 The Architectural Motifs of Folded RNAs .................... 141
Valérie Fritsch and Eric Westhof
8 Genesis and Biological Applications of Locked Nucleic
Acids (LNAs) ............................................... 175
Harleen Kaur and Souvik Maiti
9 Small Non-coding RNA in Bacteria ........................... 199
Sabine Brantl
10 MicroRNA-guided Gene Silencing ............................. 223
Gunter Meister
11 Nucleic Acid-based Therapies ............................... 233
Britta Hoehn and John J. Rossi
12 Innate Immune Recognition of Nucleic Acids ................. 261
Stefan Bauer
13 Light-responsive Nucleic Acids for the Spatiotemporal
Control of Biological Processes ............................ 279
Alexander Heckel and Günter Mayer
14 DNA Methylation ............................................ 307
Albert Jeltsch and Renata Z. Jurkowska
15 Frameworks for Programming RNA Devices ..................... 323
Maung Nyan Win, Joe C. Liang and Christina D. Smolke
16 RNA as a Catalyst: The Diels-Alderase Ribozyme ............. 339
Andres Jäschke
17 Evolving an Understanding of RNA Function by In Vitro
Approaches ................................................. 355
Qing Wang and Peter J. Unrau
18 The Chemical Biology of Aptamers: Synthesis and
Applications ............................................... 377
Günter Mayer and Bernhard Wulffen
19 Nucleic Acids as Detection Tools ........................... 401
Jeffrey C.F. Lam, Sergio Aguirre and Yingfu Li
20 Bacterial Riboswitch Discovery and Analysis ................ 433
Tyler D. Ames and Ronald R. Breaker
Index ......................................................... 455
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