Preface ....................................................... vii
Endoplasmic Reticulum Stress Sensing in the Unfolded Protein
Response ........................................................ 1
Brooke M. Gardner, David Pincus, Katja Gotthardt, Ciara
M. Gallagher, and Peter Walter
Protein-Folding Homeostasis in the Endoplasmic Reticulum and
Nutritional Regulation ......................................... 17
David Ron and Heather P. Harding
The Mammalian Endoplasmic Reticulum-Associated Degradation
System ......................................................... 31
James A. Olzmann, Ron R. Kopito, and John C. Christianson
The Endoplasmic Reticulum-Associated Degradation Pathways of
Budding Yeast .................................................. 47
Guillaume Thibault and Davis T.W. Ng
Protein Folding in the Endoplasmic Reticulum ................... 63
Ineke Braakman and Daniel N. Hebert
Disulfide Bond Formation in the Mammalian Endoplasmic
Reticulum ...................................................... 81
Neil J. Bulleid
Endoplasmic Reticulum Structure and Interconnections with
Other Organelles ............................................... 93
Amber R. English and Gia K. Voeltz
Lipid Transport between the Endoplasmic Reticulum and
Mitochondria .................................................. 109
Vid V. Flis and Günther Daum
The Role of the Endoplasmic Reticulum in Peroxisome
Biogenesis .................................................... 131
Lazar Dimitrov, Sheung Kwan Lam, and Randy Schekman
How Viruses Use the Endoplasmic Reticulum for Entry,
Replication, and Assembly ..................................... 143
Takamasa Inoue and Billy Tsai
The Contribution of Systematic Approaches to Characterizing
the Proteins and Functions of th Endoplasmic Reticulum ........ 161
Maya Schuldiner and Jonathan S. Weissman
Cell Biology of the Endoplasmic Reticulum and the Golgi
Apparatus through Proteomics .................................. 175
Jeffrey Smirle, Catherine E, Au, Michael Jain, Kurt
Dejgaard, Tommy Nilsson, and John Bergeron
Nonvesicular Lipid Transfer from the Endoplasmic Reticulum .... 191
Sima Lev
Sphingolipid Homeostasis in the Endoplasmic Reticulum and
Beyond ........................................................ 207
David K. Breslow
Endoplasmic Reticulum Targeting and Insertion of Tail-
Anchored Membrane Proteins by the GET Pathway ................. 223
Vladimir Denic, Volker Dötsch, and Irmgard Sinning
Protein Translocation across the Rough Endoplasmic Reticulum .. 235
Elisabet C. Mandon, Steven F. Trueman, and Reid Gilmore
W-Linked Protein Glycosylation in the Endoplasmic Reticulum ... 249
Jörg Breitling and Markus Aebi
The Highly Conserved COPII Coat Complex Sorts Cargo from the
Endoplasmic Reticulum and Targets It to the Golgi ............. 265
Christopher Lord, Susan Ferro-Novick, and Elizabeth
A. Miller
Functional Insights from Studies on the Structure of the
Nuclear Pore and Coat Protein Complexes ....................... 279
Thomas Schwartz
Expanding Proteostasis by Membrane Trafficking Networks ....... 291
Darren M. Hutt and William E. Balch
Retrograde Traffic from the Golgi to the Endoplasmic
Reticulum ..................................................... 313
Anne Spang
Index ......................................................... 323
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