FOREWORD ...................................................... vii
PREFACE ........................................................ ix
CONTRIBUTORS ................................................... xi
CHAPTER 1 C-H FUNCTIONALIZATION: A NEW STRATEGY FOR THE
SYNTHESIS OF BIOLOGICALLY ACTIVE NATURAL PRODUCTS ............... 1
Sophie Rousseaux, Benoоt Liégault, and Keith Fagnou
CHAPTER 2 THE NEGISHI CROSS-COUPLING IN THE SYNTHESIS OF
NATURAL PRODUCTS AND BIOACTIVE MOLECULES ....................... 33
Evelina Colacino, Jean Martinez, and Frédéric Lamaty
CHAPTER 3 METAL-CATALYZED C-HETEROATOM CROSS-COUPLING
REACTIONS ...................................................... 77
Renata Marcia de Figueiredo, Jean Marc Campagne, and Damien
Prim
CHAPTER 4 GOLDEN OPPORTUNITIES IN THE SYNTHESIS OF NATURAL
PRODUCTS AND BIOLOGICALLY ACTIVE COMPOUNDS .................... 111
Fabien Gagosz
CHAPTER 5 METATHESIS-BASED SYNTHESIS OF COMPLEX BIOACTIVES ... 155
Jean-Alexandre Richard, Sin Yee Ng, and David Y.-K. Chen
CHAPTER 6 ENANTIOSELECTTVE ORGANOCATALYSIS: A POWERFUL
TOOL FOR THE SYNTHESIS OF BIOACTIVE MOLECULES ................. 189
Mitsuru Shoji and Yujiro Hayashi
CHAPTER 7 ASYMMETRIC PHASE-TRANSFER CATALYSIS ................ 213
Seiji Shirakawa, Shin A. Moteki, and Keiji Maruoka
CHAPTER 8 REARRANGEMENTS IN NATURAL PRODUCT SYNTHESIS ........ 243
José Marco-Contelles and Elena Soriano
CHAPTER 9 DOMINO REACTIONS IN THE ENANTIOSELECTTVE
SYNTHESIS OF ВЮАСТГУЕ NATURAL PRODUCTS ........................ 271
Lutz F. Tietze, Scott G. Stewart, and Alexander Düfert
CHAPTER 10 FLUOROUS LINKER-FACILITATED SYNTHESIS OF
BIOLOGICALLY INTERESTING MOLECULES ............................ 335
Wei Zhang
CHAPTER 11 THE EVOLUTION OF IMMOBILIZED REAGENTS AND THEIR
APPLICATION IN FLOW CHEMISTRY FOR THE SYNTHESIS OF NATURAL
PRODUCTS AND PHARMACEUTICAL COMPOUNDS ........................ 359
Rebecca M. Myers, Kimberley A. Roper, Ian R. Baxendale, and
Steven V. Ley
CHAPTER 12 SYNTHETIC APPROACHES TO BIOACTIVE CARBOHYDRATES .... 395
Xavier Guinchard, Sйbastien Picard, and David Crich
CHAPTER 13 AMMONIUM YLIDES AS BUILDING BLOCKS FOR ALKALOID
SYNTHESIS ..................................................... 433
Scott Bur and Albert Padwa
CHAPTER 14 PRECURSOR-DIRECTED BIOSYNTHESIS OF POLYKETIDE
AND NONRIBOSOMAL PEPTIDE NATURAL PRODUCTS ..................... 485
Colin J.B. Harvey and Chaitan Khosla
CHAPTER 15 TARGET-ORIENTED AND DIVERSITY-ORIENTED ORGANIC
SYNTHESIS ..................................................... 513
Raphaël Rodriguez
CHAPTER 16 DNA AS A TOOL FOR MOLECULAR DISCOVERY .............. 539
Michael Њmietana, Jean-Jacques Vasseur, Janine Cossy, and
Stellios Arseniyadis
INDEX ......................................................... 557
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