G protein-coupled receptors: structure, signaling, and physiology / ed. by S.Siehler, G.Milligan. - Cambridge; New York: Cambridge University Press, 2011. - xvi, 430 p.: ill. (some col.). - Incl. bibl. ref. - Ind.: p.415-430. - ISBN 978-0-521-11208-6  Место хранения:   056 | Институт химической биологии и фундаментальной медицины CO РАН | Новосибирск| Библиотека

Оглавление / Contents

List of Figures ............................................... vii List of Tables ................................................. xi List of Contributors ......................................... xiii Introduction .................................................... 1 PART I: ADVANCES IN GPCR PROTEIN RESEARCH 1 The evolution of the repertoire and structure of С protein-coupled receptors .................................... 5 Torsten Schöneberg, Kristin Schröck, Claudia Stäubert, and Andreas Russ 2 Functional studies of isolated CPCR-C protein complexes in the membrane bilayer of lipoprotein particles ............ 32 Adam J. Kuszak, Xiao Jie Yao, Sören С. F. Rasmussen, Brian К. Kobilka, and Roger K. Sunahara PART II: OLIGOMERIZATION OF GPCRS 3 GPCR-G protein fusions: Use in functional dimerization analysis .................................................... 53 Graeme Milligan 4 Time-resolved FRET approaches to study GPCR complexes ....... 67 Jean Phillipe Pin, Damien Maurel, Laetitia Comps-Agrar, Carine Monnier, Marie-Laure Rives, Etienne Doumazane, Philippe Rondard, Thierry Durroux, Laurent Prézeau, and Erin Trinquet 5 Signaling of dopamine receptor homo- and heterooligomers .... 90 Ahmed Hasbi, Brian F. O'Dowd, and Susan R. George 6 Functional consequences of chemokine receptor dimerization ............................................... 111 Mario Mellado, Carlos Martínez-A., and José Miguel Rodríguez-Frade PART III: GPCR SIGNALING FEATURES 7 G protein functions identified using genetic mouse models ..................................................... 125 Stefan Offermanns 8 Kinetics of GPCR, G protein, and effector activation ....... 145 Peter Hein 9 RGS-RhoGEFs and other RGS multidomain proteins as effector molecules in GPCR-dependent and GPCR-independent cell signaling ............................................. 159 José Vázquez-Prado and J. Silvio Gutkind 10 Adenylyl cyclase isoform-specific signaling of GPCRs ....... 189 Karin F.К. Ejendal, Julie A. Przybyla, and Val J. Watts 11 G protein-independent and β arrestin-dependent GPCR signaling .................................................. 217 Zhongzhen Nie and Yehia Daaka 12 Assays to read GPCR modulation and signaling ............... 231 Ralf Heilker and Michael Wolff PART IV: LIGAND PHARMACOLOGY OF GPCRS 13 Assessing allosteric ligand-receptor interactions .......... 247 Ivan Toma Vranesic and Daniel Hoyer 14 7TM receptor functional selectivity ........................ 270 Terry Kenakin PART V: PHYSIOLOGICAL FUNCTIONS AND DRUG TARGETING OF GPCRS 15 β-Adrenoceptors in cardiovascular and respiratory diseases ................................................... 287 Michele Ciccarelli, J. Kurt Chuprun, and Walter J. Koch 16 Role of metabotropic glutamate receptors in CNS disorders .................................................. 321 Richard M. O'Connor and John F. Cryan 17 S1P receptor agonists, a novel generation of immunosuppressants ......................................... 380 Rosa López Almagro, Gema Tarrasón, and Nuria Godessart 18 Wnt/Frizzled receptor signaling in osteoporosis ............ 398 Georges Rawadi Index ......................................................... 415 Color plates follow page 32.