Preface ....................................................... vii
Editors ........................................................ ix
Contributors ................................................... xi
Chapter 1 Overview of Recent Developments in the Mass
Spectrometry of Nucleic Acid and Constituents ........ 1
Joseph H. Banoub, Judith Miller-Banoub, Farid
Jahouh, Nicolas Joly, and Patrick Martin
Chapter 2 Mass Spectrometric Analysis of Deoxyinosines ........ 91
Antonio Triolo
Chapter 3 Tandem Mass Spectrometry of Nucleic Acids .......... 105
Jiong Yang and Kristina Håkansson
Chapter 4 Mass Spectrometric Application in the Study of
Cyclic Nucleotides in Biochemical Signal
Transduction ....................................... 127
Russell P. Newton
Chapter 5 Analysis of Urinary Modified Nucleosides by Mass
Spectrometry ....................................... 163
Ed Dudley
Chapter 6 Mass Spectrometric Determination of DNA Adducts
in Human Carcinogenesis ............................ 195
Filip Lemière
Chapter 7 Sequence Distribution of Nucleobase Adducts
Studied by Isotope Labeling of DNA-Mass
Spectrometry ....................................... 257
Natalia Y. Tretyakova
Chapter 8 Electrospray Mass Spectrometry of Noncovalent
Complexes between Small Molecule Ligands and
Nucleic Acids ...................................... 283
Valérie Gabelica
Chapter 9 Electrospray Ionization-Mass Spectrometry for the
Investigation of Protein-Nucleic Acid
Interactions ....................................... 303
Daniele Fabris, Kevin B. Turner, and Nathan
A. Hagan
Chapter 10 Characterization of Noncovalent Complexes of
Nucleic Acids with Peptides and Proteins by Mass
Spectrometry ....................................... 329
William Buchmann
Chapter 11 MALDI-TOF Detection of Specific Noncovalent
Complexes of Highly Acidic Biomolecules with
Pyrenemethylguanidinium ............................ 371
Michael Smietana, Keiichiro Ohara, and Jean-
Jacques Vasseur
Chapter 12 Quantitative Identification of Nucleic Acids via
Signature Digestion Products Detected Using Mass
Spectrometry ....................................... 397
Mahmud Hossain and Patrick A. Limbach
Chapter 13 Electrospray Ionization Mass Spectrometry for the
Direct Analysis of Modified Nucleosides in Small
RNAs ............................................... 423
C. Callie Coombs and Patrick A. Limbach
Chapter 14 LC-MS/MS for the Examination of the Cytotoxic and
Mutagenic Properties of DNA Lesions In Vitro and
In Vivo ............................................ 431
Chunang Gu, Haizheng Hong, and Yinsheng Wang
Chapter 15 Influence of Metal Ions on the Structure and
Reactivity of Nucleic Acids ........................ 445
Janna Anichina and Diethard K. Bohme
Index ......................................................... 479
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