Target pattern recognition in innate immunity / ed. by U.Kishore. - New York: Springer Science+Business Media; Austin: Landes Bioscience, 2009. - xx, 202 p.: ill. - (Advances in experimental medicine and biology; Vol.653). - Incl. bibl. ref. - Ind.: p.199-202. - ISBN 978-1-4419-0900-8  Место хранения:   01 | ГПНТБ СО РАН | Новосибирск

Оглавление / Contents

1 MACROPHAGE PATTERN RECOGNITION RECEPTORS IN IMMUNITY, HOMEOSTASIS AND SELF TOLERANCE ............................... 1 Subhankar Mukhopadhyay, Annette Plüddemann and Siamon Gordon Abstract ........................................................ 1 Introduction .................................................... 1 The Scavenger Receptor Family ................................... 3 Class A Scavenger Receptors ..................................... 4 SR-A(SR-Ami) .................................................... 4 MARCO ........................................................... 5 SRCL-I/CLP-1 .................................................... 5 C-Type Lectin Receptors ......................................... 6 C-Type Lectins with a Single CRD ................................ 7 C-Type Lectins with Multiple CRDs ............................... 7 NK-Like C-Type Lectin-Like Receptors ........................... 10 Self Tolerance in Innate Immunity .............................. 10 Conclusion ..................................................... 11 2 PATTERN RECOGNITION BY TOLL-LIKE RECEPTORS ..................... 15 Stefan Bauer, Thomas Müller and Svetlana Hamm Abstract ....................................................... 15 Introduction ................................................... 15 Toll-Like Receptors and Their Ligands .......................... 15 Bacterial Recognition by TLRs .................................. 16 Viral Recognition by TLRs ...................................... 18 Recognition of Fungi and Protozoan Parasites by TLRs ........... 19 Cellular Localization of TLRs .................................. 20 Recognition of Endogenous Ligands by TLRs and Involvement in Autoimmunity ................................................... 20 TLR Signaling .................................................. 23 Interferon Production by TLRs .................................. 24 TLR Structure .................................................. 25 TLR Expression in Cells of the Adaptive Immune System .......... 26 Conclusion ..................................................... 27 3 NOD-LIKE RECEPTORS—PIVOTAL GUARDIANS OF THE IMMUNOLOGICAL INTEGRITY OF BARRIER ORGANS .................................... 35 Philip Rosenstiel and Stefan Schreiber Abstract ....................................................... 35 Introduction ................................................... 35 NOD-Like Receptors—Phylogenetically Ancient Molecular Platforms of the Innate Immune System .......................... 36 Modular Domain Structure ....................................... 37 NLRs and the Recent Rise of Barrier Diseases ................... 40 Plasticity of NLR Function ..................................... 42 Conclusion ..................................................... 44 4 TOLL-LIKE RECEPTORS AND NOD-LIKE RECEPTORS: DOMAIN ARCHITECTURE AND CELLULAR SIGNALLING ........................... 48 Tanja Langefeld, Walid Mohamed, Rohit Ghai and Trinad Chakraborty Abstract ....................................................... 48 Introduction ................................................... 48 Toll-Like Receptors ............................................ 48 Myd88 Dependent TLR Signalling ................................. 52 Myd88 Independent TLR Signalling ............................... 53 Nod-Like Receptors ............................................. 53 Conclusion ..................................................... 55 5 HUMORAL PATTERN RECOGNITION MOLECULES: MANNAN-BINDING LECTIN AND FICOLINS ................................................... 58 Steffen Thiel and Mihaela Gadjeva Abstract ....................................................... 58 Introduction ................................................... 58 Biochemistry ................................................... 59 Biology ........................................................ 63 Conclusion ..................................................... 68 6 LUNG SURFACTANT PROTEINS A AND D AS PATTERN RECOGNITION PROTEINS ....................................................... 74 Patrick Waters, Mudit Vaid, Uday Kishore and Taruna Madan Abstract ....................................................... 74 Introduction ................................................... 74 Collectin Structure Overview ................................... 75 N-Terminal Region .............................................. 75 Collagen Region ................................................ 75 Neck Region .................................................... 77 Carbohydrate Recognition Domain (CRD) .......................... 77 SP-A and SP-D Bind Lipid via Their CRDs ........................ 80 Calcium Ions Are Required for CRD Function ..................... 80 Factors Affecting Interaction with Polysaccharides ............. 80 Directing the Immune Response .................................. 82 Specific Examples of SP-A and SP-D as PRRs ..................... 82 Fungus and Yeast ............................................... 86 Viruses ........................................................ 87 SP-A and SP-D in Protection against Allergens and Pulmonary Hypersensitivity ............................................... 88 Phenotype and Susceptibility of SP-A and SP-D Gene Deficient Mice ........................................................... 89 Conclusion ..................................................... 91 7 PATTERN RECOGNITION BY PENTRAXINS .............................. 98 Alok Agrawal, Prem Prakash Singh, Barbara Bottazzi, Cecilia Garlanda and Alberto Mantovani Abstract ....................................................... 98 Pentraxins ..................................................... 98 Short Pentraxins: CRP and SAP .................................. 99 Long Pentraxin: PTX3 .......................................... 103 Conclusion .................................................... 107 8 TARGET PATTERN RECOGNITION BY COMPLEMENT PROTEINS OF THE CLASSICAL AND ALTERNATIVE PATHWAYS ............................ 117 Yu-Hoi Kang, Lee Aim Tan, Maria V. Carroll, Madeleine E. Gentle and Robert B. Sim Abstract ...................................................... 117 The Complement System ......................................... 117 Clq and C1 Structure .......................................... 118 Biosynthesis of Сlq ........................................... 118 Target Recognition by C1q ..................................... 120 Structural Basis of Clq Binding to Targets .................... 122 C1q Receptors ................................................. 123 C1q across the Animal Kingdom ................................. 124 Properdin and the Alternative Pathway ......................... 124 9 PATTERN RECOGNITION IN PHAGOCYTIC CLEARANCE OF ALTERED SELF ... 129 Yoshinobu Nakanishi, Peter M. Henson and Akiko Shiratsuchi Abstract ...................................................... 129 Roles and Mechanisms of Phagocytosis .......................... 129 Recognition of Altered Self by Phagocytes ..................... 132 Consequences of Phagocytic Clearance of Apoptotic Cells ....... 137 Fate of Necrotic Cells or Cells Dying by Other Modes .......... 137 Conclusion .................................................... 138 10 STRUCTURAL BASIS OF PATTERN RECOGNITION BY INNATE IMMUNE MOLECULES ..................................................... 139 Eamon P. McGreal Abstract ...................................................... 139 Introduction .................................................. 139 Molecules Containing Leucine Rich Repeats (LRRs) .............. 140 Carbohydrate Recognition by C-Type Lectin and C-Type Lectin- Like Molecules ................................................ 147 Emerging Innate Immune Pattern Recognition Molecules .......... 151 Conclusion .................................................... 155 11 LESSONS FROM THE FLY: PATTERN RECOGNITION IN DROSOPHILA MELANOGASTER ....................................... 162 Subhamoy Pal and Louisa P. Wu Introduction .................................................. 162 The Immune Response in the Fly ................................ 163 The Pattern Recognition Receptors ............................. 164 Conclusion .................................................... 171 12 IMMUNE RECOGNITION OF PLASMODIUM-INFECTED ERYTHROCYTES ........ 175 Damien V. Cordery and Britta C. Urban Malaria ....................................................... 175 Clinical Immunity to P. falciparum Infection .................. 175 Involvement of Pattern Recognition Receptors in Plasmodium Infection ..................................................... 177 Recognition of Plasmodium-iRBCs by Toll-Like Receptors ........ 178 Recognition of Plasmodium-iRBCs by Scavenger Receptors ........ 179 Conclusion .................................................... 179 13 INNATE IMMUNE RECOGNITION IN TUBERCULOSIS INFECTION ........... 185 Anthony G. Tsolaki Abstract ...................................................... 185 Introduction .................................................. 185 Receptor-Mediated Phagocytosis of M. tuberculosis ............. 186 Complement Receptors .......................................... 186 Mannose Receptors ............................................. 186 Scavenger Receptors ........................................... 187 Survival of M. tuberculosis inside the Phagosome .............. 188 Immune Recognition of M. tuberculosis ......................... 189 Cytokines Induced in Response to M. tuberculosis Infection .... 191 Conclusion .................................................... 194 INDEX ............................................................ 199