Imaging the aging brain / ed. by W.Jagust, M.D'Esposito. - Oxford; New York: Oxford University Press, 2009. - xiii, 368 p.: ill. (some col.). - Incl. bibl. ref. - Ind.: p.361-368. - ISBN 978-0-19-532887-5  Место хранения:   054 | Международный томографический центр CO РАН | Новосибирск

Оглавление / Contents

Preface ........................................................ ii 1. Introduction: Still More Questions than Answers ............. 3 William Jagust and Mark D'Esposito 2. Methodological and Conceptual Issues in the Study of the Aging Brain ................................................ 11 Mark D'Esposito, William Jagust, and Adam Gazzaley 3. Neuropathology of Aging .................................... 27 Dara L. Dickstein, John H. Morrison, and Patrick R. Hof PART I BASIC SCIENCE 4. A Systems Approach to the Aging Brain: Neuroanatomic Changes, Their Modifiers, and Cognitive Correlates ......... 43 Naftali Raz and Kristen M. Kennedy 5. Dopaminergic Modulation of Cognition in Human Aging ........ 71 Shu-Chen Li, Ulman Lindenberger, Lars Nyberg, Hauke R. Heekeren, and Lars Bäckman 6. Cognitive Reserve and Aging ................................ 93 Yaakov Stern 7. Compensatory Reorganization of Brain Networks in Older Adults .................................................... 105 Cheryl L. Grady 8. Cross-Species Imaging Applied to the Aging Brain: Dissociating Alzheimer's Disease from Normal Aging ........ 115 Sidonie T. Jones and Scott A. Small 9. Genetics and Imaging in Alzheimer's Disease ............... 123 Susan Y. Bookheimer PART II CLINICAL APPLICATIONS 10. Imaging Cognitive Decline in Aging: Predicting Decline with Structural Imaging ................................... 135 Jeffrey Kaye 11. The Early Detection of Alzheimer's Disease with Positron Emission Tomography ....................................... 151 Rachel Mistur, Lisa Mosconi, Remigiusz Switalski, Susan De Santi, Yi Li, Lidia Glodzik, Miroslaw Brys, Wai Tsui, Henry Rusinek, and Mony J. de Leon 12. Structural Imaging of Mild Cognitive Impairment ........... 169 Clifford R. Jack, Jr. 13. Functional Imaging with FDG-PET in Mild Cognitive Impairment ................................................ 183 Karl Herholz 14. Amyloid Imaging and (What is "Normal"?) Aging ............. 191 William E. Klunk and Chester A. Mathis 15. Differential Diagnosis of Dementia Using Functional Neuroimaging .............................................. 245 Eric Salmon, Fabienne Collette, and Gaёtan Garraux 16. MRI and the Differential Diagnosis of Dementia ............ 261 António J. Bastos-Leite and Philip Scheltens 17. White Matter Hyperintensities in Aging and Dementia ....... 273 Adriane Mayda, Mitsuhiro Yoshita, and Charles DeCarli 18. Functional MRI Studies in Aging and Early Alzheimer's Disease: Predicting Clinical Decline ...................... 293 Reisa Sperling 19. MRI as a Surrogate Marker in Clinical Trials in Alzheimer's Disease ....................................... 305 Frank Jessen and Harald Hampel 20. Brain Imaging in the Evaluation of Putative Alzheimer's Disease-Slowing, Risk-Reducing and Prevention Therapies ... 319 Eric M. Reiman and Jessica B.S. Langbaum 21. Databasing the Aging Brain ................................ 351 John Darrell Van Horn and Arthur W. Toga Index ......................................................... 361