Mass spectrometry in drug metabolism and pharmacokinetics (Hoboken, 2009). - ОГЛАВЛЕНИЕ / CONTENTS
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ОбложкаMass spectrometry in drug metabolism and pharmacokinetics / ed. by R.Ramanathan. - Hoboken: Wiley, 2009. - xii, 389 p.: ill. - Incl. bibl. ref. - Ind.: p.383-389. - ISBN 978-0-471-75158-8
 

Оглавление / Contents
 
Preface ....................................................... vii
About the Editor ............................................... ix
Contributors ................................................... xi

1.  Evolving Role of Mass Spectrometry in Drug Discovery
    and Development ............................................. 1
       Dil M. Ramanathan and Richard M. LeLacheur

2.  Quantitative Bioanalysis in Drug Discovery and
    Development: Principles and Applications ................... 87
       Ayman El-Kattan, Chris Holliman, and Lucinda H. Cohen

3.  Quadrupole, Triple-Quadrupole, and Hybrid Linear Ion
    Trap Mass Spectrometers for Metabolite Analysis ........... 123
       Elliott B. Jones

4.  Applications of Quadrupole Time-of-Flight Mass
    Spectrometry in Reactive Metabolite Screening ............. 159
       Jose M. Castro-Perez

5.  Changing Role of FTMS in Drug Metabolism ................... 191
       Petia A. Shipkova, Jonathan L. Josephs, and
       Mark Sanders

6.  High-Resolution LC-MS-Based Mass Defect Filter Approach:
    Basic Concept and Application in Metabolite Detection ..... 223
       Haiying Zhang, Donglu Zhang, Mingshe Zhu, and
       Kenneth L. Ray

7.  Applications of High-Sensitivity Mass Spectrometry and
    Radioactivity Detection Techniques in Drug Metabolism
    Studies ................................................... 253
       Wing W. Lam, Cho-Ming Loi, Angus Nedderman, and
       Don Walker

8.  Online Electrochemical-LC-MS Techniques for Profiling
    and Characterizing Metabolites and Degradants ............. 275
       Paul H. Gamache, David F. Meyer, Michael C. Granger,
       and Ian N. Acworth

9.  LC-MS Methods with Hydrogen/Deuterium Exchange for
    Identification of Hydroxylamine, N-Oxide, and
    Hydroxylated Analogs of Desloratadine ..................... 295
       Natalia A. Penner, Joanna Zgoda-Pols, Ragu
       Ramanathan, Swapan K. Chowdhury, and Kevin B. Alton

10. Turbulent-Flow LC-MS: Applications for Accelerating
    Pharmacokinetic Profiling and Metabolite Identification ... 311
       Joseph L. Herman and Joseph M. Di Bussolo

11. Desorption Ionization Techniques for Quantitative
    Analysis of Drug Molecules ................................ 341
       Jason S. Gobey, John Janiszewski, and Mark J. Cole

12. MALDI Imaging Mass Spectrometry for Direct Tissue
    Analysis of Pharmaceuticals ............................... 359
       Yunsheng Hsieh and Walter A. Korfmacher

INDEX ......................................................... 383


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