Preface ....................................................... vii
About the Editors .............................................. ix
Contributors ................................................... xi
PART I Overview ............................................. 1
Chapter 1 Introduction ......................................... 3
Frank T. Robb, Garabed Antranikian, Dennis
W. Grogan, and Arnold J.M. Driessen
PART II Molecular Basis of Thermostability ................... 7
Chapter 2 Compatible Solutes of (Hyper)thermophiles and Their
Role in Protein Stabilization ........................ 9
Helena Santos, Pedro Lamosa, Tiago Q. Faria,
Tiago M. Pais, Manuela Lopez de la Paz, and
Luis Serrano
Chapter 3 Relationships among Catalytic Activity, Structural
Flexibility, and Conformational Stability as
Deduced from the Analysis of Mesophilic-
Thermophilic Enzyme Pairs and Protein
Engineering Studies ................................. 25
Reinhard Sterner and Eike Brunner
Chapter 4 Membranes and Transport Proteins of Thermophilic
Microorganisms ...................................... 39
Sonja Verena Albers and Arnold J.M. Driessen
Chapter 5 Thermophilic Protein-Folding Systems ................ 55
Frank T. Robb and Pongpan Laksanalamai
Chapter 6 Physical Properties of Membranes Composed of
Tetraether Archaeal Lipids .......................... 73
Parkson Lee-Gau Chong
PART III Heat-Stable Enzymes and Metabolism .................. 97
Chapter 7 Glycolysis in Hyperthermophiles ..................... 99
Peter Schönheit
Chapter 8 Industrial Relevance of Thermophiles and Their
Enzymes ............................................ 113
Garabed Antranikian
Chapter 9 Denitrification Pathway Enzymes of Thermophiles .... 161
Simon de Vries and Imke Schröder
PART IV Genetics of Thermophiles ........................... 177
Chapter 10 DNA Stability and Repair ........................... 179
Malcolm F. White and Dennis W. Grogan
Chapter 11 Plasmids and Cloning Vectors for Thermophilic
Archaea ............................................ 189
Kenneth M. Stedman
Chapter 12 Genetic Analysis in Extremely Thermophilic
Bacteria: An Overview .............................. 205
Dennis W. Grogan
Chapter 13 Targeted Gene Disruption as a Tool for
Establishing Gene Function in Hyperthermophilic
Archaea ............................................ 213
Haruyuki Atomi and Tadayuki Imanaka
Chapter 14 Nanobiotechnological Potential of Viruses of
Hyperthermophilic Archaea .......................... 225
Tamara Basta and David Prangishvili
PART V Minimal Complexity Model Systems ................... 237
Chapter 15 Master Keys to DNA Replication, Repair, and
Recombination from the Structural Biology of
Enzymes from Thermophiles .......................... 239
Li Fan, R. Scott Williams, David S. Shin, Brian
Chapados, and John A. Tainer
Chapter 16 DNA Replication in Thermophiles .................... 265
Jae-Ho Shin, Lori M. Kelman, and Zvi Kelman
Chapter 17 DNA-Binding Proteins and DNA Topology .............. 279
Kathleen Sandman
Chapter 18 Structure and Evolution of the Thermus
thermophilus Ribosome .............................. 291
Steven T. Gregory and Albert E. Dahlberg
Chapter 19 Protein Phosphorylation at 80°C and Above .......... 309
Peter J. Kennelly
Chapter 20 Archaeal 20S Proteasome: A Simple and
Thermostable Model System for the Core Particle .... 333
Joshua K. Michel and Robert M. Kelly
Index ......................................................... 347
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