Contemporary approaches to modelling, optimisation and control of biotechnological processes (Sofia, 2010). - ОГЛАВЛЕНИЕ / CONTENTS
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ОбложкаContemporary approaches to modelling, optimisation and control of biotechnological processes / U.Viesturs et al.; ed. by S.Tzonkov. - Sofia: Prof. Marin Drinov Academic Publishing House, 2010. - 241 p.: ill. - ISBN 978-954-322-384-8
 

Оглавление / Contents
 
Foreword ........................................................ 7
Short biographical data of prof. Stoyan Tzonkov ................. 9
Preface ........................................................ 13

Chapter 1. Modelling of yeast fed-batch cultivation using 
           functional state approach

1.1  Introduction .............................................. 17
1.2  Theoretical background of the functional state modelling
     approach .................................................. 18
1.3  Application of functional state modelling approach to S.
     cerevisiae cultivations ................................... 20
     1.3.1  Modelling of first fed-batch cultivation of S.
            cerevisiae ......................................... 21
     1.3.2  Modelling of second fed-batch cultivation .......... 26
     1.3.3  Modelling of third fed-batch cultivation ........... 31
1.4  Analysis and conclusions .................................. 36
1.5  References ................................................ 39

Chapter 2. Modelling and control of the anaerobic digestion
           of organic wastes in continuously stirred tank
           bioreactors

2.1  Introduction .............................................. 41
2.2  Mass balance models ....................................... 42
     2.2.1  Model based on one stage reaction scheme ........... 42
     2.2.2  Models based on two-stage scheme ................... 44
     2.2.3  Models based on three-stage scheme ................. 45
     2.2.4  Models based on more complex reaction schemes ...... 47
     2.2.5  Gas phase modelling ................................ 52
     2.2.6  Modelling of two-phase anaerobic digestion
            process ............................................ 53
     2.2.7  Anaerobic digestion model N1 ....................... 54
2.3  Optimisation and control .................................. 55
     2.3.1  Process factors control considerations ............. 55
     2.3.2  Optimal control of the process ..................... 56
     2.3.3  Static optimisation ................................ 56
     2.3.1  Optimal start-up ................................... 60
     2.3.5  Dynamical optimisation ............................. 66
     2.3.6  Linearizing control of the anaerobic digestion
            with addition of acetate ........................... 67
     2.3.7  Extremum seeking control ........................... 70
2.4  Conclusions ............................................... 73
     2.5  Acknowledgements ..................................... 73
     2.6  References ........................................... 74

Chapter 3. Control and stabilization of the growth rate of
           fed-batch cultivation processes

3.1  Introduction .............................................. 77
3.2  Description of a general enlarged Monod kinetic model ..... 78
3.3  Brunovsky normal form of Wang-Monod kinetic model and
     "time minimization" optimal control ....................... 80
3.4  Stabilization of the fed-batch process in the optimal
     growth rate - Wang-Monod kinetic model .................... 85
     3.4.1. Optimal profile and determination of moment t1
     and moment t2 - Wang-Monod model .......................... 88
3.5. Equivalent form of Wang-Yerusalimsky kinetic models and
     growth rate control ....................................... 92
3.6  Sliding mode control and stabilization of the
     cultivation process in the "best" growth rate ............. 94
3.7  Determination of the "best" growth rate of the
     cultivation process as maximum of a utility function ...... 96
3.8  Discussions .............................................. 101
3.9  Conclusions .............................................. 102
3.10 References ............................................... 103

Chapter 4. Genetic algorithms for static optimisation of
           fed-batch fermentation processes

4.1  Introduction ............................................. 105
4.2  Theoretical background of genetic algorithms ............. 109
     4.2.1  History of genetic algorithms ..................... 109
     4.2.2  What are genetic algorithms? ...................... 110
     4.2.3  Structure of a simple GA .......................... 111
4.3  Genetic algorithms for feeding trajectory optimization ... 115
4.4  Description of fed-batch fermentation processes of
     E. coli .................................................. 119
     4.4.1  Fed-batch cultivation of E. coli MC4110 ........... 119
     4.4.2  Fed-batch cultivation of E. coli BL21(DE3)pPhyt
            109 ............................................... 119
4.5  Application of genetic algorithms for feeding
     trajectory optimization .................................. 121
     4.5.1  Feeding trajectory optimization of E. coli
            MC4110 ............................................ 121
     4.5.2  Feeding trajectory optimization of E. coli
            BL21(DE3)pPhytl09 ................................. 126
4.6  Conclusion ............................................... 132
4.7  Acknowledgements ......................................... 134
4.8  References ............................................... 134

Chapter 5. Multiple objective optimisation of fermentation
           process

5.1  Introduction ............................................. 137
5.2  Kinetic model and systems variables constrains ........... 139
     5.2.1  Kinetic model of the process ...................... 139
     5.2.2  System constraints ................................ 141
5.3  Multiple objective optimisation problem .................. 142
     5.3.1  Problem formulations .............................. 142
     5.3.2  Fuzzy-decision-making problem ..................... 145
5.4  Results and discussions .................................. 150
5.5  Conclusions .............................................. 154
5.6. References ............................................... 155

Chapter 6. Neuro-dynamic, rollout and model predictive
           control of fermentation processes

6.1  Introduction ............................................. 157
6.2  Neuro-dynamic optimal control of fermentation
     processes ................................................ 159
     6.2.1. Optimal control of whey fermentation process
            using NDP ......................................... 162
6.3  Model predictive control of fermentation processes ....... 165
6.4  Rollout optimal control of fermentation process .......... 171
     6.4.1  Rollout optimal control method .................... 171
     6.4.2  Optimal control of whey fermentation process
            using Rollout method .............................. 177
6.5  Conclusions .............................................. 179
6.6  References ............................................... 179

Chapter 7. Sliding mode controller with boundary layer for
           yeast fed-batch cultivation

7.1  Introduction ............................................. 181
7.2  Development of sliding mode controller with boundary
     layer .................................................... 183
7.3  Comparison of conventional PI controller and sliding
     mode controller with boundary layer ...................... 190
7.4  Analysis and conclusions ................................. 197
7.5  References ............................................... 197

Chapter 8. Process control case studies: flexible and
           user-friendly fermentation process controller

8.1  Introduction ............................................. 199
8.2  Principle of the bioprocess controller BIO-3 design ...... 202
8.3  Description of algorithms ................................ 207
     8.3.1  Fermentation process temperature control .......... 207
     8.3.2  Thermostat overheating control .................... 207
     8.3.3  Volume control .................................... 208
     8.3.4  pH control ........................................ 209
     8.3.5  Foam control ...................................... 210
     8.3.6  Pressure control .................................. 211
     8.3.7  Feeding control ................................... 212
     8.3.8  pO2 control ....................................... 212
8.4  Application examples ..................................... 218
     8.4.1  Equipment ......................................... 218
     8.4.2  Materials and methods ............................. 220
     8.4.3  Fed-batch cultivation of Saccharomyces
            cerevisiae with cascade control of pO2 ............ 222
     8.4.4  Saccharomyces cerevisiae fed-batch fermentations
            with different variants of pH control ............. 229
8.5  Conclusions .............................................. 232
8.6  Acknowledgements ......................................... 233
8.7  References ............................................... 233
     Curricula vitae of the authors ........................... 237


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