Autonomic Neurotransmission: 60 Years Since Sir Henry Dale
Geoffrey Burnstock ........................................... 1
The Role of Gβγ Subunits in the Organization, Assembly, and
Function of GPCR Signaling Complexes
Denis J. Dupré, Mélanie Robitaille, R. Victor Rebois,
and Terence E. Hébert ....................................... 31
Pharmacology of Nicotine: Addiction, Smoking-Induced Disease,
and Therapeutics
Neal L. Benowitz ............................................ 57
Targeting Proteins for Destruction by the Ubiquitin System:
Implications for Human Pathobiology
Alan L. Schwartz and Aaron Ciechanover ...................... 73
Progress in Genetic Studies of Pain and Analgesia
Michael L. LaCroix-Fralish and Jeffirey S. Mogil ............ 97
Lipid Mediators in Health and Disease: Enzymes and Receptors
as Therapeutic Targets for the Regulation of Immunity and
Inflammation
Takao Shimizu .............................................. 123
Sorting out Astrocyte Physiology from Pharmacology
Todd A. Fiacco, Cendra Agulhon, and Ken D. McCarthy ........ 151
Lithium's Antisuicidal Efficacy: Elucidation of
Neurobiological Targets Using Endophenotype Strategies
Colleen E. Kovacsics, Irving I. Gottesman, and Todd
D. Gould ................................................... 175
Global and Site-Specific Quantitative Phosphoproteomics:
Principles and Applications
Boris Macek, Matthias Mann, and Jesper V. Olsen ............ 199
Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein
Interaction to Reactivate p53 Function: A Novel Approach for
Cancer Therapy
Sanjeev Shangary and Shaomeng Wang ......................... 223
Epigenetics, DNA Methylation, and Chromatin Modifying Drugs
Moshe Szyf ................................................. 243
The COXIB Experience: A Look in the Rearview Mirror
Lawrence J. Marnett ........................................ 265
Quantitative Disease, Drug, and Trial Models
Jogarao V.S. Gobburu and Lawrence J. Lesko ................. 291
Immunodrugs: Therapeutic VLP-Based Vaccines for Chronic
Diseases
Gary T. Jennings and Martin F. Bachmann .................... 303
Akt/GSK3 Signaling in the Action of Psychotropic Drugs
Jean-Martin Beaulieu, Raul R. Gainetdinov, and Marc G.
Caron ...................................................... 327
Topical Microbicides to Prevent HIV: Clinical Drug
Development Challenges
Craig W. Hendrix, Yingjun Cao, and Edward J. Fuchs ......... 349
Emerging Pharmacology: Inhibitors of Human Immunodeficiency
Virus Integration
Daria Hazuda, Marian Iwamoto, and Larissa Wenning .......... 377
The TRPC Class of Ion Channels: A Critical Review of Their
Roles in Slow, Sustained Increases in Intracellular Ca2+
Concentrations
Lutz Birnbaumer ............................................ 395
Mycobacterial Subversion of Chemotherapeutic Reagents and
Host Defense Tactics: Challenges in Tuberculosis Drug
Development
Liem Nguyen and Jean Pieters ............................... 427
Indexes
Contributing Authors, Volumes 45-49 ........................... 455
Chapter Titles, Volumes 45-49 ................................. 458
Errata
An online log of corrections to Annual Review of
Pharmacology and Toxicology articles may be found at
http://pharmtox.annualreviews.org/errata.shtml
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