Preface ......................................................... v
Contributors ................................................... xi
1. Glucose Metabolism in Brain
1.1. Bioenergetics ........................................... 3
D.G. Nicholls
1.2. Glucose, Oxidative Energy Metabolism, and Neural
Function in Brain Slices-Glycolysis Plays a Key
Role in Neural Activity ................................ 17
Y. Okada, P. Lipton
1.3. Pentose Phosphate Pathway and NADPH Metabolism ......... 41
R. Dringen, H.H. Hoepken, T. Minich, C. Ruedig
1.4. The Cerebral Tricarboxylic Acid Cycles ................. 63
T.B. Rodrigues, S. Cerdan
1.5. Electron Transport. Structure, Redox-Coupled
Protonmotive Activity, and Pathological Disorders
of Respiratory Chain Complexes ......................... 93
S. Papa, V. Petruzzella, S. Scacco
1.6. The Mitochondrial F1F0 ATP Synthase ................... 119
A. Gaballo, S. Papa
2. Alternative Substrates
2.1 The Support of Energy Metabolism in the Central
Nervous System with Substrates Other than Glucose ...... 137
E.L. Roberts, Jr
3. Metabolic Specialization of Brain Cell Types and
Compartmentation of Function
3.1 Anaplerosis ............................................ 183
B. Hassel
3.2 Glial-Neuronal Shuttle Systems ......................... 197
С. Zwingmann, D. Leibfritz
4. Molecular and Cellular Architecture Link Energy Demand
with Metabolite Fluxes
4.1. Cytoplasmic Glycolytic Enzymes. Synaptic Vesicle-
Associated Glycolytic ATP-Generating Enzymes:
Coupling to Neurotransmitter Accumulation ............. 241
T. Ueda, A. Ikemoto
4.2. Mitochondrial Architecture and Heterogeneity .......... 261
G.A. Perkins, M.H. Ellisman
4.3. Coupling of Neuronal Function to Oxygen and Glucose
Metabolism Through Changes in Neurotransmitter
Dynamics as Revealed with Aging, Hypoglycemia, and
Hypoxia ............................................... 297
J.A. Joseph, G.E. Gibson
4.4. Coupling of Brain Function and Metabolism:
Endogenous Flavoprotein Fluorescence Imaging of
Neural Activities by Local Changes in Energy
Metabolism ............................................ 321
K. Shibuki, R. Hishida, H. Kitaura,
K. Takahashi, M. Tohmi
4.5. Coupling of Brain Function to Metabolism:
Evaluation of Energy Requirements ..................... 343
A. Gjedde
4.6. Energy Consumption by Phospholipid Metabolism in
Mammalian Brain ....................................... 401
A.D. Purdon, S.I. Rapoport
4.7. Ion Transport and Energy Metabolism ................... 429
O. Vergun, K.E. Dineley, I.J. Reynolds
5. Regulation of Metabolic Fluxes and Metabolic Shuttling
by Neural Environment
5.1. Acid-Base Transport and pH Regulation ................. 469
J.W. Deitmer
5.2. Nitric Oxide in Regulation of Mitochondrial
Function, Respiration, and Glycolysis ................. 487
J.P. Bolanos, A. Almeida
5.3. Mitochondrial Production of Oxidants and Their
Role in the Regulation of Cellular Processes .......... 519
P.S. Brookes
5.4. Uncoupling Proteins ................................... 549
J.S. Kim-Han, S.S. Ali, L.L. Dugan
5.5. Actions of Toxins on Cerebral Metabolism at the
Cellular Level ........................................ 569
U. Sonnewald, T. Syversen, A. Schousboe,
H. Waagepetersen, M. Aschner
6. Interaction of Mitochondria with Cytosol and Other
Organelles
6.1. Mitochondrial/Cytosolic Interactions via Metabolite
Shuttles and Transporters ............................. 589
K.F. LaNoue, V. Carson, D.A. Berkich, S.M. Hutson
6.2. Mitochondrial-Endoplasmic Reticulum Interactions ...... 617
G. Szabadkai, R. Rizzuto
6.3. Mitochondria-Nucleus Energetic Communication: Role
for Phosphotransfer Networks in Processing Cellular
Information ........................................... 641
P.R. Dzeja, A. Terzic
6.4. Mitochondrial Permeability Transition in the
CNS-Composition, Regulation, and Pathophysiological
Relevance ............................................. 667
T. Wieloch, G. Mattiasson, M.J. Hansson,
E. Elmer
6.5. Mitochondrial Mechanisms of Oxidative Stress and
Apoptosis ............................................. 703
L. Soane, N. Solenski, G. Fiskum
7. Genes of Metabolism: Generating, Sustaining, and
Modifying the Machinery of Energy Metabolism.
Regulation of Gene Expression for Metabolic Enzymes
7.1. Proteomics ........................................... 737
M.H. Maurer, W. Kuschinsky
7.2. Genetics and Gene Expression of Glycolysis ............ 771
J.C. LaManna, P. Pichiule, J.C. Chavez
7.3. Transcriptional Integration of Mitochondrial
Biogenesis ............................................ 789
R.С. Scarpulla
8. Metabolic Control Analysis: Modeling Local Pathway
Fluxes, Control Points, System Interactions, Network
Interactions
8.1. Mechanisms and Modeling of Energy Transfer Between
Intracellular Compartments ............................ 815
V.A. Saks, M. Vendelin, M.K. Aliev,
T. Kekelidze, J. Engelbrecht
8.2. Modeling of Regulation of Glycolysis and Overall
Energy Metabolism Under a Systems Biology Approach .... 861
M. Cascante, L.G. Bows, J. Boren
8.3. Modeling of Electron Transport: Implications
to Mitochondrial Diseases ............................. 877
J-P. Mazat. M. Beurton-Aimar, B. Faustin,
T. Letellier, M. Malgat, C. Nazaret,
R. Rossignol
8.4. Metabolomics: Concepts and Potential Neuroscience
Applications .......................................... 889
B.S. Kristal, R. Kaddurah-Daouk, M.F. Beal,
W.R. Matson
Index ......................................................... 913
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