Foreword ....................................................... xi
Editor ....................................................... xiii
Contributors ................................................... xv
Part I Fundamentals and Methodologies ........................... 1
Chapter 1. Introduction to Capillary Electrophoresis ............ 3
James P. Landers
Chapter 2. Protein Analysis by Capillary Electrophoresis ....... 75
James M. Hempe
Chapter 3. Micellar Electrokinetic Chromatography ............. 109
Shigeru Terabe
Chapter 4. Capillary Electrophoresis for Pharmaceutical
Analysis ........................................... 135
Eamon McEvoy, Alex Marsh, Kevin Altria,
Sheila Donegan, and Joe Power
Chapter 5. Principles and Practice of Capillary
Electrochromatography .............................. 183
Myra T. Koesdjojo, Carlos F. Gonzalez, and
Vincent T. Remcho
Chapter 6. Capillary Electrophoresis of Nucleic Acids ......... 227
Eszter Szántai and András Guttman
Chapter 7. Analysis of Carbohydrates by Capillary
Electrophoresis .................................... 251
Julia Khandurina
Chapter 8. The Coupling of Capillary Electrophoresis and
Mass Spectrometry in Proteomics .................... 295
Haleem J. Issaq and Timothy D. Veenstra
Chapter 9. Light-Based Detection Methods for Capillary
Electrophoresis .................................... 305
Cory Scanlan, Theodore Lapainis, and
Jonathan V. Sweedler
Chapter 10.Microfluidic Devices for Electrophoretic
Separations: Fabrication and Use ................... 335
Lindsay A. Legendre, Jerome P. Ferrance, and
James P. Landers
Part IIA. Capillary-Based Systems: Core Methods and
Technologies ........................................ 359
Chapter 11.Kinetic Capillary Electrophoresis .................. 361
Maxim V. Berezovski and Sergey N. Krylov
Chapter 12.DNA Sequencing and Genotyping by Free-Solution
Conjugate Electrophoresis .......................... 381
Jennifer A. Coyne, Jennifer S. Lin, and
Annelise E. Barron
Chapter 13.Online Sample Preconcentration for Capillary
Electrophoresis .................................... 413
Dean S. Burgi and Braden C. Giordano
Chapter 14.Capillary Electrophoresis for the Analysis of
Single Cells: Sampling, Detection, and
Applications ....................................... 429
Imee G. Arcibal, Michael F. Santillo, and
Andrew G. Ewing
Chapter 15.Ultrafast Electrophoretic Separations .............. 445
Michael G. Roper, Christelle Guillo, and
B. Jill Venton
Chapter 16.DNA Sequencing by Capillary Electrophoresis ........ 467
David L. Yang, Rachel Sauvageot, and Stephen
L. Pentoney, Jr.
Chapter 17.Dynamic Computer Simulation Software for
Capillary Electrophoresis .......................... 515
Michael C. Breadmore and Wolfgang Thormann
Chapter 18.Heat Production and Dissipation in Capillary
Electrophoresis .................................... 545
Christopher J. Evenhuis, Rosanne M. Guijt,
Miroslav Маска, Philip J. Marriott, and
Paul R. Haddad
Chapter 19.Isoelectric Focusing in Capillary Systems .......... 563
Jiaqi Wu, Tiemin Huang, and Janusz Pawliszyn
Part IIB. Capillary-Based Systems: Specialized Methods and
Technologies .................................... 581
Chapter 20.Subcellular Analysis by Capillary
Electrophoresis .................................... 583
Bobby G. Рое and Edgar A. Arriaga
Chapter 21.Chemical Cytometry: Capillary Electrophoresis
Analysis at the Level of the Single Cell ........... 611
Colin Whitmore, Kimia Sobhani, Ryan Bonn,
Danqian Mao, Emily Turner, James Kraly,
David Michels, Monica Palcic, Ole Hindsgaul,
and Norman J. Dovichi
Chapter 22.Glycoprotein Analysis by Capillary
Electrophoresis .................................... 631
Michel Girard, Izaskun Lacunza, Jose Carlos
Diez-Masa, and Mercedes de Frutos
Chapter 23.Capillary Electrophoresis of Post-Translationally
Modified Proteins and Peptides .................... 707
Bettina Sarg and Herbert H. Lindner
Chapter 24.Extreme Resolution in Capillary Electrophoresis:
UHVCE, FCCE, and SCCE .............................. 723
Wm. Hampton Henley and James W. Jorgenson
Chapter 25.Separation of DNA for Forensic Applications
Using Capillary Electrophoresis .................... 761
Lilliana I. Moreno and Bruce McCord
Chapter 26.Clinical Application of CE ......................... 785
Zak K. Shihabi
Chapter 27.Solid-Phase Microextraction and Solid-Phase
Extraction with Capillary Electrophoresis and
Related Techniques ................................. 811
Stephen G. Weber
Chapter 28.CE-SELEX: Isolating Aptamers Using Capillary
Electrophoresis .................................... 825
Renee К. Mosing and Michael T. Bowser
Chapter 29.Microfluidic Technology as a Platform to
Investigate Microcirculation ....................... 841
Dana M. Spence
Chapter 30.Capillary Electrophoresis Applications for
Food Analysis ...................................... 853
Belinda Vallejo-Cordoba and Maria Gabriela
Vargas Martinez
Chapter 31.Separation Strategies for Environmental Analysis ... 913
Fernando G. Tonin and Marina F.M. Tavares
Part IIIA. Microchip-Based: Core Methods and Technologies ..... 979
Chapter 32.Cell Manipulation at the Micron Scale .............. 981
Thomas M. Keenan and David J. Beebe
Chapter 33.Multidimensional Microfluidic Systems for
Protein and Peptide Separations ................... 1001
Don L. DeVoe and Cheng S. Lee
Chapter 34.Microchip Immunoassays ............................ 1013
Kiichi Sato and Takehiko Kitamori
Chapter 35.Solvent Extraction on Chips ....................... 1021
Manabu Tokeshi and Takehiko Kitamori
Chapter 36.Electrophoretic Microdevices for Clinical
Diagnostics ....................................... 1037
Jerome P. Ferrance
Chapter 37.Advances in Microfluidics: Development of
a Forensic Integrated DNA Microchip (IDChip) ...... 1065
Katie M. Horsman and James P. Landers
Chapter 38.Taylor Dispersion in Sample Preconcentration
Methods ........................................... 1085
Rajiv Bharadwaj, David E. Huber, Tarun
Khurana, and Juan G. Santiago
Chapter 39.The Mechanical Behavior of Films and Interfaces
in Microfluidic Devices: Implications for
Performance and Reliability ....................... 1121
Matthew R. Begley and Jennifer Monahan
Chapter 40.Practical Fluid Control Strategies for
Microfluidic Devices .............................. 1153
Christopher J. Easley and James P. Landers
Chapter 41.Low-Cost Technologies for Microfluidic
Applications ...................................... 1169
Wendell Karlos Tomazelli Coltro and Emanuel
Carrilho
Chapter 42.Microfluidic Reactors for Small Molecule and
Nanomaterial Synthesis ............................ 1185
Andrew J. deMello, Christopher J. Cullen,
Robin Fortt, and Robert C.R. Wootton
Part IIIB. Microchip-Based: Specialized Methods and
Technologies ...................................... 1205
Chapter 43.Sample Processing with Integrated Microfluidic
Systems ........................................... 1207
Joan M. Bienvenue and James P. Landers
Chapter 44.Cell and Particle Separation and Manipulation
Using Acoustic Standing Waves in Microfluidic
Systems ........................................... 1229
Thomas Laurell and Johan Nilsson
Chapter 45.Optical Detection Systems for Microchips .......... 1253
James M. Karlinsey and James P. Landers
Chapter 46.Microfabricated Electrophoresis Devices for
High-Throughput Genetic Analysis: Milestones
and Challenges .................................... 1277
Charles A. Emrich and Richard A. Mathies
Chapter 47.Macroporous Monoliths for Chromatographic
Separations in Microchannels ...................... 1297
Frantisek Svec and Timothy B. Stachowiak
Chapter 48.Microdialysis and Microchip Systems ............... 1327
Barbara A. Fogarty, Pradyot Nandi, and Susan
M. Lunte
Chapter 49.Microfluidic Sample Preparation for Proteomics
Analysis Using MALDI-MS ........................... 1341
Simon Ekstrom, Johan Nilsson, Gyorgy Marko-
Varga, and Thomas Laurell
Chapter 50.Implementing Sample Preconcentration in
Microfluidic Devices .............................. 1375
Paul M. van Midwoud and Elisabeth Verpoorte
Chapter 51.Using Phase-Changing Sacrificial Materials
to Fabricate Microdevices for Chemical Analysis ... 1419
Hernan V. Fuentes and Adam T. Woolley
Chapter 52.Materials and Modification Strategies for
Electrophoresis Microchips ........................ 1441
Charles S. Henry and Brian M. Dressen
Chapter 53.Microfluidic Devices with Mass Spectrometry
Detection ......................................... 1459
lulia M. Lazar
Chapter 54.Nanoscale Self-Assembly of Stationary Phases
for Capillary Electrophoresis of DNA .............. 1507
Kevin D. Dorfman and Jean-Louis Viovy
Chapter 55.Nanoscale DNA Analysis ............................ 1527
Laili Mahmoudian, Mohamad Reza Mohamadi,
Noritada Kaji, Manabu Tokeshi, and Yoshinobu Baba
Index ........................................................ 1543
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